华中科技大学基础医学院教授，博士生导师。1999年毕业于安徽大学，获学士学位。2005年毕业于中国科学技术大学，获博士学位。2005－2010年在美国加州理工学院（Caltech）从事博士后/研究助理。“国家杰出青年基金”获得者，担任中国生物物理学会线粒体生物学分会副会长、中国细胞生物学学会细胞器分会委员、湖北省细胞生物学学会理事。主要研究线粒体动态调控和质量控制的分子机制及功能，开发线粒体、溶酶体、内质网等研究新技术新方法，研究线粒体及相关细胞器在肝脏疾病、心血管疾病、肿瘤及神经退行性疾病等发生发展中作用及分子机制，探索线粒体相关疾病干预及诊治的新靶点和新策略。

1. Jun Dong^#, Li Chen^#, Fei Ye^#, Junhui Tang, Bing Liu, Jiacheng Lin, Pang-Hu Zhou, Bin Lu, Min Wu, Jia-Hong Lu, Jing-Jing He, Simone Engelender, Qingtao Meng, Zhiyin Song*, He He*. (2024). Mic19 depletion impairs endoplasmic reticulum-mitochondrial contacts and mitochondrial lipid metabolism and triggers liver disease. Nature Communications. 15(1):168

2. Tianshu Hao^#, Jianglong Yu^#, Zhida Wu, Jie Jiang, Longlong Gong, Bingjun Wang, Hanze Guo, Huabin Zhao, Bin Lu, Simone Engelender, He He*, Zhiyin Song* (2023) Hypoxia-reprogramed megamitochondrion contacts and engulfs lysosome to mediate mitochondrial self-digestion. Nature Communications. 14(1):4105

3. Li Chen^#, Jun Dong^#, Siyang Liao, Siyou Wang, Zhida Wu, Meiling Zuo, Bing Liu, Chaojun Yan, Yong Chen, He He, Qingtao Meng*, Zhiyin Song*. (2022) Loss of Sam50 in hepatocytes induces cardiolipin-dependent mitochondrial membrane remodeling to trigger mtDNA release and liver injury. Hepatology. 76(5):1389-1408

4. Siyang Liao; Li Chen; Zhiyin Song*; He He*. (2022) The fate of damaged mitochondrial DNA in the cell, Biochimica et Biophysica Acta - Molecular Cell Research, 1869(5): 119233

5.  Li Shu^#, Chao Hu^#, Meng Xu, Jianglong Yu, He He, Jie Lin, Hongying Sha, Bin Lu, Simone Engelende, Minxin Guan, Zhiyin Song*. (2021) ATAD3B is a mitophagy receptor mediating clearance of oxidative stress-induced damaged mitochondrial DNA. The EMBO Journal. 40(8):e106283

6. Zhida Wu^#, Meiling Zuo^#, Ling Zeng, Kaisa Cui, Bing Liu, Chaojun Yan, Li Chen, Jun Dong, Fugen Shangguan, Wanglai Hu, He He, Bin Lu, Zhiyin Song*. (2021) OMA1 reprograms metabolism under hypoxia to promote colorectal cancer development. EMBO Reports. 22(1):e50827

7. Junhui Tang^#, Kuan Zhang^#, Jun Dong, Chaojun Yan, Chao Hu, Hongchao Ji, Liangyi Chen, Shi Chen, Huabin Zhao, Zhiyin Song*. (2020) Sam50-Mic19-Mic60 axis determines mitochondrial cristae architecture by mediating mitochondrial outer and inner membrane contact. Cell Death and Differentiation. 27(1):146-160

8. Chaojun Yan, Longlong Gong, Li Chen, Meng Xu, Hussein Abou-Hamdan, Mingliang Tang, Laurent Désaubry, Zhiyin Song* (2020) PHB2 (prohibitin 2) promotes PINK1-PRKN/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis. Autophagy. 16(3):419-434

9. Chao Hu^#, Li Shu^#, Xiaoshuai Huang, Jianglong Yu, liuju Li, Longlong Gong, Meigui Yang, Zhida Wu, Zhi Gao, Yungang Zhao, Liangyi Chen*, and Zhiyin Song* (2020) OPA1 and MICOS Regulate Mitochondrial Crista Dynamics and Formation. Cell Death & Disease. 11(10):940

10. Chaojun Yan, Xiaoying Duanmu, Ling Zeng, Bing Liu, Zhiyin Song*. (2019) Mitochondrial DNA: Distribution, Mutations, and Elimination. Cells. 8(4)

11. Fenglei Jian, Dan Chen, Li Chen, Chaojun Yan, Bin Lu, Yushan Zhu, Shi Chen, Anbing Shi, David C Chan, Zhiyin Song.* (2018) Sam50 Regulates PINK1-Parkin-Mediated Mitophagy by Controlling PINK1 Stability and Mitochondrial Morphology. Cell Reports. 23(10), 2989-3005

12. Muhammad Riaz Khan, Shaoxun Xiang, Zhiyin Song*, Mian Wu* (2017) The p53-inducible long noncoding RNA TRINGS protects cancer cells from necrosis under glucose starvation. The EMBO Journal. 36(23):3483-3500

13. Li H, Ruan Y, Zhang K, Jian F, Hu C, Miao L, Gong L, Sun L, Zhang X, Chen S, Chen H, Liu D, Song Z.* (2016) Mic60/Mitofilin determines MICOS assembly essential for mitochondrial dynamics and mtDNA nucleoid organization. Cell Death and Differentiation, 23(3):380-92.

14. Kuan Zhang, Huihui Li, Zhiyin Song* (2014) Membrane depolarization activates the mitochondrial protease OMA1 by stimulating self-cleavage. EMBO Reports, 15(5):576-85

15. Y Ruan, H Li, K Zhang, F Jian, J Tang, Z Song* (2013) Loss of Yme1L perturbates mitochondrial dynamics. Cell Death & Disease, 4:e896. doi: 10.1038/cddis.2013.414

16. Miao L^#, Song Z^#, Jin L, Zhu YM, Wen LP, Wu M. (2010) ARF antagonizes the ability of Miz-1 to inhibit p53-mediated transactivation. Oncogene, 29(5):711-722 (co-first author)

17 Zhiyin Song, Mariam Ghochani, J Michael McCaffery, Terrence G Frey, David C Chan*. (2009) Mitofusins and OPA1 mediate sequential steps in mitochondrial membrane fusion. Molecular Biology of the Cell, (15):3525-3532  

18. Zhiyin Song, Hsiuchen Chen, Maja Fiket, Christiane Alexander, David C Chan. (2007) OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L. Journal of Cell Biology. 178(5):749-755

19. Zhiyin Song, Mian Wu*. (2005) Identification of a novel nucleolar localization signal and a degradation signal in Survivin-deltaEx3: a potential link between nucleolus and protein degradation. Oncogene. 14; 24(16): 2723-2734

20. Zhiyin Song, Shixin Liu, He He, Naser Hoti, Yi Wang, Shanshan Feng, Mian Wu*. (2004) A Single Amino Acid Change (Asp 53->Ala53) Converts Survivin from anti-apoptotic to pro-apoptotic. Molecular Biology of the Cell. 15(3):1287-1296

21. Zhiyin Song, Xuebiao Yao, Mian Wu. (2003) Direct interaction between Survivin and Smac is essential for the anti-apoptotic activity of Survivin during Taxol-induced apoptosis. Journal of Biological Chemistry. 278(25): 23130-23140