教授

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张华锋


教授、博士生导师、病理学系副主任


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个人简介

华中科技大学基础医学院教授、博士生导师。国家自然科学基金优秀青年基金获得者。主要研究方向为肿瘤免疫和免疫代谢,研究聚焦T细胞分化和记忆形成的免疫信号和代谢模式,探讨调控T细胞代谢及功能的关键生物学问题及其在肿瘤免疫中的作用。研究成果发表在Nature Cell BiologyNature ImmunologyMolecular CellPNASSTTT等国际主流学术期刊。


近年代表作

1. Zhang H*, Yang Z, Yuan W, Liu J, Luo X, Zhang Q, Li Y, Chen J, Zhou Y, Lv J, Zhou N, Ma J, Tang K, Huang B. Sustained AhR activity programs memory fate of early effector CD8+ T cells. Proc Natl Acad Sci U S A. 2024 Mar 12;121(11):e2317658121.

2. Gu Z, Liu J, Qin L, Zhang Y, Cui W, Huang H, Liu L, Cao Y, Zhang H*. WTAP-mediated m6A modification of IFNE is required for antiviral defense in condyloma acuminata. J Dermatol Sci. 2023 Aug;111(2):43-51.

3. Zhang H, Liu J, Yang Z, Zeng L, Wei K, Zhu L, Tang L, Wang D, Zhou Y, Lv J, Zhou N, Tang K, Ma J, Huang B. TCR activation directly stimulates PYGB-dependent glycogenolysis to fuel the early recall response in CD8+ memory T cells. Mol Cell. 2022 Jun 17:S1097-2765(22)00538-X.

4. Tang K, Zhang H, Deng J, Wang D, Liu S, Lu S, Cui Q, Chen C, Liu J, Yang Y, Li Y, Chen J, Lv J, Ma J, Huang B. Ammonia detoxification promotes CD8+ T cell memory development by urea and citrulline cycles. Nat Immunol. 2023 Jan;24(1):162-173.

5. Zhang H, Tang K, Ma J, Zhou L, Liu J, Zeng L, Zhu L, Xu P, Chen J, Wei K, Liang X, Lv J, Xie J, Liu Y, Wan Y, Huang B. Ketogenesis-generated β-hydroxybutyrate is an epigenetic regulator of CD8+ T cell memory development. Nat Cell Biol. 2020 Jan;22(1):18-25.

6. Ma R, Ji T, Zhang H, Dong W, Chen X, Xu P, Chen D, Liang X, Yin X, Liu Y, Ma J, Tang K, Zhang Y, Peng Y, Lu J, Zhang Y, Qin X, Cao X, Wan Y, Huang B. A Pck1-directed glycogen metabolic program regulates formation and maintenance of memory CD8+ T cells. Nat Cell Biol. 2018;20:21-27.

7. Zhang H, Yu Y, Zhou L, Ma J, Tang K, Xu P, Ji T, Liang X, Lv J, Dong W, Zhang T, Chen D, Xie Jing, Liu Y, Huang B. Circulating tumor microparticles promote lung metastasis by reprogramming inflammatory and mechanical niches via a macrophage-dependent pathway. Cancer Immunol Res. 2018;6:1046-56.







  • 华中科技大学同济医学院病理学系
    华中科技大学同济医学院附属同济医院病理研究所(科) 
    湖北省武汉市航空路13号 邮编:430030