副教授

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程洁




联系方式:jiecheng2024@hust.edu.cn

8320


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个人简介

华中科技大学基础医学院病理系、博士生导师。2020年毕业于北京大学获博士学位。2020年-2024年在清华大学从事博士后工作。主要研究方向为肿瘤免疫,关注使用代谢组学、CRISPR筛选、单细胞组学和空间组学等技术,研究肿瘤免疫逃逸的机制和筛选抗肿瘤免疫的新靶点。另外一个研究方向为免疫衰老,关注从代谢的角度,研究免疫衰老的机制和逆转免疫衰老以降低老年性疾病风险(比如肿瘤)。


近年代表作

1. Cheng J#, Xiao Y#, Peng T#, Zhang Z#, Qin Y#, Zhang Z*, Li C*, Zhu H*, Jiang P*. ETV7 limits anti-tumor efficacy of CD8+ T cells by diverting their fate towards exhaustion. Nature Cancer. 2024, in press.

2. Cheng J#, Yan J#, Liu Y#, Shi J#, Zhang X*, Zhu H*, Jiang P*. Cancer cell-derived fumarate suppresses the anti-tumor capacity of CD8+T cells in the tumor microenvironment. Cell metabolism. 2023 May 5;S1550-4131(23)00171-7.

3. Cheng J#, Liu Y#, Yan J#, Zhang XX*, Jiang P*. Fumarate suppresses B-cell activation and function through direct inactivation of LYN. Nature chemical biology. (2022). Sep;18(9):954-962.

4. Cheng J#, Huang Y, Zhang X, Yu Y, Wu S, Jiao J, Tran L, Zhang W, Liu R, Zhang L, Wang M, Wang M, Yan W, Wu Y, Chi F, Jiang P, Zhang X, Wu H*. TRIM21 and PHLDA3 negatively regulate the crosstalk between the PI3K/AKT pathway and PPP metabolism. Nat Commun. Article number: 1880 (2020)

5. Cheng J#, Li W#, Kang B#, Zhou Y, Song J, Dan S, Yang Y, Zhang X, Li J, Yin S, Cao H, Yao H, Zhu C, Yi W, Zhao Q, Xu X, Zheng M, Zheng S, Li L, Shen B, Wang YJ*. 2015 Jun Tryptophan derivatives regulate the transcription of Oct4 in stem-like cancer cells. Nat Commun.10;6:7209. doi: 10.1038/ncomms8209.

6. Chen T#, Xie S#, Cheng J, Wu H, Jiang P*. AKT1 phosphorylation of cytoplasmic ME2 induces a metabolic switch to glycolysis for tumorigenesis. Nature communications. 2024 Jan 23;15(1):686. doi: 10.1038/s41467-024-44772-8.

7. Liu Y, Chen YN, Cheng J, Yan JX, Xue CY, Pan HY, Shen XY, Zhou J, Jiang P*, Zhou YL*, Zhang XX*. Ultrasensitive HPLC-MS Quantification of S-(2-Succino) Cysteine Based on Ethanol/Acetyl Chloride Derivatization in Fumarate Accumulation Cells. Anal Chem. (2023) 2023 Jan 10. doi: 10.1021/acs.analchem.2c03573.








  • 华中科技大学同济医学院病理学系
    华中科技大学同济医学院附属同济医院病理研究所(科) 
    湖北省武汉市航空路13号 邮编:430030